报告题目：Metabolic engineering for ginseng sapogenin and saponin production in transgenic plants

       报告人：Yong Eui Choi

       Department of Forest Resources, College of Forest and Environmental Science, Kangwon National University, Chuncheon 200-701, South Korea

       时间：2018年12月10日14:00

       地点：生命科学学院608会议室

       报告简介：Ginsenosides, a class of tetracyclic triterpene saponins, are synthesized from dammarenediol-II which initially was converted into sapogenin after hydroxylation by the cytochrome P450 (CYP) enzymes and finally into saponin after glycosylation by the glycosyltransferases. Previously, we functionally characterized the dammarenediol synthases (PgDDS) and two CYP genes (CYP716A47 and CYP716A53v2) involved in dammarene-type ginsenoside biosynthesis in Panax ginseng (Han et al. 2006, 2013, 2014). These findings of genes are amenable to proceed metabolic engineering for production of ginseng sapogenins and saponins. Recently, we established the production system of dammarenediol-II, protopanaxadiol, protopanaxatriol, and compound K via metabolic engineering of tobacco. The production of dammarenediol-II, protopanaxadiol, protopanaxatriol, and compound K was highly fostered in cell suspension culture of transgenic tobacco cells. These engineered products will be applicable to the sources for pharmaceutical and cosmetic products.

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